The HLA complex
 

HLA genes lie within the human major histocompatibility complex .
These genes are on chromosome 6 and their prescence is associated with certain diseases.


The HLA complex - İACR

Please note normal healthy people may posess the genes without getting the disease concerned.

However an interaction between the gene and certain environmental agents may precipitate the disease.

Examples:

Disease

HLA marker

Relative risk

Ankylosing Spondylitis

B27

90

Reiters Syndrome

B27

41

Psoriatic Arthritis

B27

10

Inflammatory bowel disease and spondylitis

B27

10

Rheumatoid arthritis

DR4

6

Polyarticular Juvenile RA

DR4

7

Pauciarticular Juvenile RA

DR8

5

Juvenile Dermatomyositis

DR3

4

SLE

DR2
DR3

3
6

Sjogrens

DR3

6

The test in isolation is therefore NOT of diagnostic help and the significance of the test depends on the context of the disease you suffer from or are suspected of having.
For example certain DR4 gene subtypes are associated with a more severe RA.

However - as I say often - the real issue is the Clinical status and not the blood test.....The test is NOT diagnostic of ANY disease.

Therefore your Rheumatologist will interpret the results in the context of your clinical presentation.

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