|Methotrexate : by drdoc on-line|
Methotrexate is an excellent disease modifying drug for a whole host
of rheumatic diseases - especially RA and Psoriatic arthritis / spondyloarthropathy
patients, and also may be used in other spondyloarthropathies - including ankylosing
spondylitis. It is used weekly. .. starting dose approx. 7.5 - 10 mg WEEKLY. Psoriatics
often require more dosage.
It has several potential side effects.
I will list some of the most common here :
1 Nausea- especially when first used.
The tabs can be divided up on the day of use to reduce this effect.
The side effects are lessened by
addition of FOLIC ACID VITAMIN B 5mg / day.
Side effects sound bad - but the
disease (RA) is a SERIOUS ONE and the side effects are less than the problems of the
disease itself. However only active synovitis will benefit - not the burned out stage
-where the disease has already ravaged the joints and left bony changes without active
Encourage an aggressive approach from your doctors- and especially a SPECIALIST OPINION. One thing is for sure- Such medications require an expert and that means Speak to your RHEUMATOLOGIST, who will know the potential problems and what to expect from these drugs.
More recently - in the past few years - the drug has found a great place in the management of Juvenile Chronic Arthritis (JCA) / Juvenile Rheumatoid arthritis (JRA), although not yet registered for this use by the FDA in USA at this time.
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Dr David Gotlieb