|Minocycline in the treatment of rheumatoid arthritis :||
by drdoc on-line
They have been many theories of an infective cause for rheumatoid
arthritis. These have included Epstein barr virus, mycoplasma, rubella virus,
and many other claimed agents. For many years, Minocycline and the tetracyclines were
advocated for treatment of rheumatoid arthritis by Thomas McPherson Brown. The studies
done by Brown however received much criticism because of study methods and protocol.
Studies were poorly controlled and much of the data unsubstantiated.
However more recently, studies have been performed looking at tetracyclines in rheumatoid arthritis.
The tetracyclines have many potential influences against rheumatic disease.
1. An immunomodulating action by inhibition of
lymphocyte proliferation and differentiation.
Most studies now show Minocycline to have some efficacy in
rheumatoid arthritis when compared to placebo. These results do not show definite
difference in preventing disease progression.
The side effect profile of Minocycline include:
The usual dose of Minocycline in the studies was 100 mg twice daily.
Further studies are required to confirm the place of Minocycline
in the management of Rheumatoid arthritis.