Polyarteritis Nodosa (PAN) - is a serious disease and has a VERY high mortality unless treated with immunosuppression...usually in the form of prednisone and Cyclophosphamide.
It essentially consists of an inflammatory reaction in the wall of blood vessels - resulting in occlusion of the vessels and starvation of the tissues of blood flow and oxygen. The result is severe tissue damage. The blood vessel wall is infiltrated with neutrophil white cells.
The organs most affected in PAN are the
Skin - with ulceration.
The illness is usually characterized
Males are usually affected more than females and are usually young.
There is often a long delay in diagnosis, often months and it is a problem that should be considered in many multisystem diseases which are otherwise diagnostically difficult and unexplained.
The investigations show :
Therapy MUST be aggressive.
The untreated 5 year survival is 13%.
information of the Treatment
of Polyarteritis Nodosa and the necrotizing vasculitidies
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Dr David Gotlieb