Tetracyclines and Antibiotics
Theory / hypothesis: The Tetracyclines and hypothesis of RA - by drdoc on-line
I see the minocycline as having a mild
to medium disease modifying activity in RA.
IN ALL only one GOOD PLACEBO CONTROLLED trial exists to suggest that minocycline is efficacious in RA.
However most people would say it has a mild effect... but FOR SOME PATIENTS it is highly effective.
It would seem that
It has some effect in 1/3 of patients.
Therefore I see it as having a place in patients who haven't responded to standard DMARDS. It would be nice to see a trial in patients early in their disease- i.e. the first few months.
The Disease I feel is a multifactorial
Antibiotics don't treat viruses too effectively, but tetracyclines have a antiinflammatory, and an anticollaganase and an immunosuppressive role. This may explain its effect. I am unaware of any specific articles showing antiviral activity.
That's the theory of drdoc.
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